Heart rate is also phenotype-coupled: near zero at 1 mg in the obese trial cohort, but +10 bpm or more at the same 1 mg in a leaner body from Phase 1b
Its often described as a quick, slight pinch or sting at the injection site, lasting only a few seconds
The 11-12% average weight loss at the highest dose could be exactly what they need, without the intensity of a dual-receptor agonist
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Some people are interested in using very low doses of GLP-1 medications (like semaglutide or tirzepatide) for potential benefits beyond weight loss such as reducing inflammation, improving metabolic health, or supporting longevity