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Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPAR and histone acetylation

Liraglutide was found to activate osteoblast proliferation by promoting the Wnt signaling pathway and p-AMPK/PGC1 signaling pathway, and inhibit osteoclast activation by suppressing the OPG/RANKL/RANK signaling pathway through anti-inflammatory, antioxidant, and anti autophagic pathways, thereby reversing bone loss ( There are certain limitations of this study that should be noted

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This attenuates their endocrine production of circulating IGF-I despite excessive GH secretion (84)

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