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Certain antioxidants that remain unreactive with Fe 3 -based reagents, such as FRAP, or Fe 3 to Fe 2 transformation methods (e.g., thiols), are effectively oxidized by the CUPRAC reagent

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Most clinical trials and FDA approvals focus on adolescents 12 and older with obesity or related health complications (such as type 2 diabetes or high blood pressure)

Best for long-term storage when aliquoted and frozen, but requires careful handling to avoid degradation