In some specific protocols, yes, but physiological saline (0.9% NaCl) contains no preservative, so it has shorter solution stability, similar to sterile water
You can be one step away from healthy and functioning or have full-blown Addisons disease, an autoimmune disease where your immune system attacks your adrenal glands and damages your adrenal cortex
How significant is this adverse signal
The components of the matrix secreted by fibroblasts can directly interact with membrane receptors, like integrins and syndecans, and initiate intracellular signalling pathways which play important roles in various processes like organ morphogenesis, cell migration or mechanotransduction ( Fibroblasts are involved not only in the deposition of ECM components, but also in their appropriate remodelling through crosslinking and proteolysis
doi: 10.3390/foods10010106 178 HuangMXieXNYuanRXinQQMaSDGuoHGet al
Thyroid 15 , 12871290 (2005)