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Melatonin also exerts antiestrogenic activity, which is particularly significant in hormone-dependent tumors, regulating the expression and transactivation of the estrogen receptor, and modulating the enzymes involved in the local synthesis of estrogens

Nature 131, 325

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The Commission justified this approach as follows: [8] The systematic names and formulas given refer to hypothetical forms in which amino groups are unprotonated and carboxyl groups are undissociated

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Dosage and Recommendations General Wellness: 200-300 mcg per day