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In accordance with this, the steady-state concentration of O 2 in the mitochondrial matrix is estimated to be five to ten times higher than that in the cytosol [56]

Proc Nat Acad Sci USA 104:1482514830 Bruijn LI, Becher MW, Lee MK et al (1997) ALS-linked SOD1 mutation G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions

1 It has been established that melatonin stimulates GPx in vivo , enhancing GPx activity, during which H 2 O 2 is metabolized to H 2 O, and glutathione (GSH) is oxidized to its disulfide form GSSG (Fig

Doing so will help to tamp down oxidative stress in and of itself