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Moreover, GLP-1R activates adenylyl cyclase (AC) to produce cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA) that activates cAMP response element-binding protein (CREB), a constitutively expressed nuclear transcription factor that regulates the expression of genes involved in inflammation [11, 12]

demonstrated, in addition to higher weight loss in the group treated with high-dose liraglutide 3.0 mg/day for 32 weeks, significant improvements not only of fasting glucose and HOMA-IR, but also of the post-load glucose measured by OGTT, OGTT-derived insulin sensitivity index (SIOGTT), and corrected the early insulin response to a glucose challenge (IGI/HOMA) compared to placebo [62]

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