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The usual explanation is dose accuracy
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Our paradigm also did not require food deprivation: in contrast to several previous laboratory-based experiments (e.g., [51, 52]), the animals were allowed to eat in an unrestrained and practically ad libitum manner (see Methods)
In CAG rats, the levels of 1-methylnicotinamide and NADP were significantly reduced, reflecting the fact that the overall level of niacin in their organisms was significantly decreased compared to normal rats
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