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Acknowledgements The work was supported by a NHLBI grant R01HL148112 (L.S.), two Stimulating and Advancing ACCM Research (StAAR) grants from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University (L.S

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NAD+ does play a background role by supplying energy for immune activity, but it does not drive toxin clearance the way glutathione does

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