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Whether long-term treatment with mecobalamin in T2DM patients with DPN harms sleep should be assessed in a future longitudinal study

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This elevation in NAD+ levels activates critical metabolic pathways including SIRT1 (sirtuin 1), a longevity-associated protein that regulates insulin sensitivity, mitochondrial function, and cellular stress resistance

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The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study