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The STEP 1 extension data showed maintained weight loss at 104 weeks, with participants maintaining an average 13.7% weight reduction from baseline

However, long-term daily laxative use can lead to dependence and electrolyte imbalances

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Biochemical parameters recorded at baseline included total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, amylase, lipase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), fasting plasma glucose, and fasting insulin