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Mild-to-moderate fatigue during the first 2-4 weeks is a normal adaptation response and does not indicate the medication is inappropriate

Semaglutide has been shown to reduce the risk of cardiovascular death, heart attack and stroke in adults who have established cardiovascular disease and obesity or are overweight

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However, tirzepatides effect on gastric emptying can alter the absorption of oral medications, so timing of any oral therapies should be discussed with a provider

The essential role of insulin-like growth factor-1 in the intestinal tropic effects of glucagon-like peptide-2 in mice