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The top three cholesterol binding sites, displaying the highest cholesterol residence times for both states, were calculated using the PyLipID package (Figure 2D, E)

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Kucukgoncu S, Zhou E, Lucas KB, Tek C. Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials. Obes Rev. 2017 May;18(5):594-601. doi: 10.1111/obr.12528. Epub 2017 Mar 13. PMID: 28295905; PMCID: PMC5523816

Denaturation is sort of a natural part of life for a protein and is somewhat unavoidable

CD44 expression on epidermal melanocytes