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Each step was clearly defined, heavily regulated, and controlled by established institutions

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Phospho-specific protein microarray detection A CSP 100 plus phospho-specific protein microarray (Full Moon Microsystems, Sunnyvale, CA, USA) was used to investigate the cell signaling profile

Sample size estimation was based on a previous clinical trial, 11 in which the within-subject variance of log (AUC 0300 min ) for acetaminophen was estimated to be 0.03 and the between-subject variance, 0.04

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3 Glutathione is an antioxidant found in the human body, contributing to drug and xenobiotic detoxification