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Cons of MTHFR Gene Mutation Testing: Limited Clinical Utility: While MTHFR mutations are associated with elevated homocysteine levels, the direct link to specific health conditions remains unclear

Proc Natl Acad Sci 110:48044809 Naureen Z, Dautaj A, Nodari S, Fioretti F, Dhuli K, Anpilogov K, Lorusso L, Paolacci S, Michelini S, Guda T, Kallazi M, Bertelli M (2021) Proposal of a food supplement for the management of post-covid syndrome

In moderate-to-severe renal impairment or end-stage renal disease (eGFR below 60 mL/min/1.73m) the label halves this to 0.025 mg/kg/day , because teduglutide is cleared renally at roughly the glomerular filtration rate [1]

For patients whose primary issue is GH-axis-driven VAT accumulation rather than total caloric excess, tesamorelin may address the root cause more directly