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[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Wang B, Su Z, Kuang M, Luo Y, Xu M, Sun M, et al

This pathway is regulated by insulin, which promotes the activation of acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), the key enzymes in fatty acid synthesis

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The latter study also identified lysosomes as a major post-endocytic GLP-1R destination, raising the possibility that prolonged agonist exposure might result in GLP-1R degradation