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Thirteen synthetic opioids were examined, with potencies ranging from similar to morphine to exceeding that of fentanyl

If fatigue remains severe despite adequate nutrition, hydration, and sleep, discuss with your provider whether dose adjustment or temporary dose delay is appropriate

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Discard it and obtain a fresh supply

Every escalation decision is reviewed by an independent Safety Review Committee, which evaluates all available data against predefined stopping rules

If back pain interferes with sleep, experiment with different sleeping positions and supportive pillows to find what works for your specific condition