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In vivo studies with 4-mercapto butyrate confirmed this pattern for systemic HIF stabilisation in mice (Ornelas et al., 2023)

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doi:10.1016/j.mimet.2005.01.010

The efficacy of receptor agonists is also different in animals with and without diabetes as levels of insulin and blood glucose can affect the pathophysiology and outcomes of stroke (185, 186)

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Another limitation in comparing these retrospective studies is the inconsistency in the outcomes by which the association of GLP-1RAs with DR was measured