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LCs express high levels of VDR, and their phenotype and functional state are profoundly influenced by local concentrations of 1,25(OH)D [139].Studies have shown that 1,25(OH)D significantly suppresses the expression of LC surface maturation markers (such as CD80, CD86, CD40, and MHC II) as well as the chemokine receptor CCR7, thereby reducing their migratory capacity to draining lymph nodes and their ability to activate nave T cells [140]

doi: 10.1177/000331976201301103 22 CohenAGoldmanJ

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This caution is not conservatism for its own sake: a systematic review and meta-analysis of laser therapy for melasma found that benefits are frequently offset by high recurrence and a real risk of rebound pigmentation, particularly in Fitzpatrick types IV to VI

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