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To integrate evidence across datasets, we performed a meta-analysis combining MR estimates from all cohorts, which allowed us to strengthen statistical power, assess effect consistency, and ensure the robustness of the observed associations across diverse populations

Zepbound and Mounjaro contain tirzepatide, which targets GIP and GLP-1 receptors

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Peptide drugs like retatrutide are broken down by digestive enzymes before absorption, making oral delivery technically challenging