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No one knows for certain, but like other autoimmune diseases, there are a number of hypotheses

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Next, slides were washed once with PBS for 5 min and incubated at 37C for 1h with either 1:1000 dilution of mouse polyclonal anti-full length-CSP (FL-CSP), 1:100 dilution of mouse polyclonal anti-NTD-GST, 1:200 dilution of anti-CSP repeats monoclonal antibody (3SP2) or with blocking solution (negative control)

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Health state utilities associated with weight loss in type 2 diabetes and obesity