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Folic acid requires a double activation (reduction) by the enzyme dihydrofolate reductase (DHFR) to which it has very low affinity so that, at higher concentrations, it behaves as a competitive inhibitor of DHFR [25] and may result in an impairment of the whole pathway

It inhibits melanin production , making the skin lighter, clearer, and more even-toned

P, phloroglucinol

Data availability All data supporting the findings of this study are included in this published article and its Supplementary Information files, and are available from the corresponding author upon request

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It has also been shown to influence lipid metabolism enzyme activity, including hormone-sensitive lipase and lipoprotein lipase, and to modulate adipogenic transcription factor expression in adipocyte differentiation models