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This paper reviews the regulatory effects of metformin on the gut microbiota, such as increasing the abundance of genus Akkermansia , enriching short-chain fatty acids (SCFAs)-producing bacterial genus, and regulating gene expression of certain genera

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Conversely, in diet-induced MASH mice lacking adaptive immunity, adoptive transfer of Treg cells worsened hepatic steatosis and increased serum ALT levels, suggesting a potentially detrimental role in this setting (137)