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Por otro lado, nos alerta de los efectos secundarios que pueden producir y que cada vez denuncian ms pacientes de Estados Unidos, donde est prctica est muy extendida

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The GLP-1R can couple to the Gs or Gq proteins, leading to increases in intracellular cAMP and/or Ca2+ levels and activation of PKA, Epac-2, phospholipase C and ERK1/2 signal transduction pathways

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