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Combined with the RMSD analysis, it can be inferred that after the fluctuation in the first 200 ns, the conformation of CME_b undergoes changes, making it more similar to the characteristics of CME_a.In the CME_c binding mode, the L1 and L4 regions exhibit significant fluctuations during the simulation (Fig

It may also help treat other types of migraines such as cluster and tension-type headaches

Competing interests All authors declare no conflict of interest

Unlike oral supplements, which face the gauntlet of our digestive system (and often get broken down, resulting in as little as 20-50% absorption), intravenous delivery bypasses the gut entirely