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Some other possible side effects that may occur include: Headache Stomach pain Fatigue Constipation Dizziness Heartburn or indigestion Low blood sugar (hypoglycemia) Bloating Gas Mood changes Although rare, they can rarely cause serious and sometimes life-threatening adverse effects such as: Severe allergic reaction Pancreatitis Gallstones Kidney problems Worsening vision (diabetic retinopathy) in type 2 diabetics Heart rate changes Suicidal thoughts or behaviors Increased risk of thyroid cancer Bowel obstruction (a blockage that keeps food from passing through your intestines) These are not all of the possible adverse effects of these medications

10.1146/annurev-biochem-061009-102430 Annu

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Furthermore, different studies employ varied sequencing methods (e.g., ITS1, ITS2, or 18S rRNA) and rely on fungal reference databases (e.g., UNITE, ITSoneDB) that are continuously updated 107,108 , which may introduce biases in species classification, lead to underdetection of low-abundance taxa, and complicate direct comparisons across studies

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