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The evidence that is currently available is not sufficient enough to suggest that a lack of vitamin B12 has any significant or specific impact on weight, regardless of whether it causes weight gain or loss

doi: 10.1111/j.1463-1326.2010.01212.x

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Last updated June 3, 2026 Editorial policy A Weight-Loss Drug With an Unexpected Benefit If youve been anywhere near the news in the past two years, youve heard of GLP-1 receptor agonists drugs like Ozempic, Wegovy, and Mounjaro that have transformed weight loss and diabetes management

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GLP-1 receptor agonist medications are synthetic versions of this hormone that work by mimicking what your body already does, just more effectively