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GLP-1s are here to stay, and digital health companies like Ro, Calibrate, WeightWatchers and hims & hers are getting in on the action
4 A history of gallbladder disease A 2022 systematic review of 76 randomised trials found that GLP-1 medications are associated with a relative risk of around 37% for gallbladder or biliary disease, with a higher relative risk in weight-loss trials than in diabetes trials
doi: 10.1038/s41419-022-05037-8 10 TanWDaiFYangDDengZGuRZhaoXet al
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157,158,159,160,161,162 The effect of PARPs to stimulate chromatin decompaction might be exerted via the steric hindrance of PAR chain, the negative charge of DNA and PAR, or the displacement of core histones
