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This narrative review covers the identification and development of incretin therapy for diabetes and obesity, culminating in the recent clinical trials of dual agonist therapy and the future prospect of tri-agonists

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Summary: Current evidence from regulatory reviews and clinical trials does not establish a causal link between GLP-1 agonists and suicidal ideation, though ongoing monitoring continues

Adjustments to the dosing schedule, additional supportive medications, or consideration of alternative weight management strategies may be appropriate

Gut Health Champion: If your focus is on gut health , BPC 157 is the go-to peptide

Keywords: Ischemic colitis, Blood flow rescue, Collaterals, BPC 157, L-NAME, L-arginine, Oxidative stress, NO, Rats Core tip: We rescued rat ischemic colitis