GHK-Cus gene modulation capacity was documented in a landmark microarray analysis by Pickart et al., identifying 4,000+ gene targets including VEGF upregulation (angiogenesis), SOD2 upregulation (oxidative defense), and downregulation of pro-inflammatory cytokine genes including TNF- and IL-6
These results may be relevant to further research into diabetes
Anecdotal evidence suggests it may help with skin lightening, though scientific data remains limited
Blood 120, 42194228 [DOI] [PMC free article] [PubMed] [Google Scholar] 86.McClure JJ et al
However, in diabetic patients, wound healing is often disrupted by multiple factors, causing dysregulation in hemostasis, inflammation, proliferation, and remodeling phases, which ultimately lead to chronic wounds
The observed injuries in the lungs, heart, kidneys, and brain share a common mechanistic hallmark: glycocalyx shedding, increased vascular permeability, neutrophil adhesion, and oxidative stress [5, 17, 21, 104]