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However, many reported GSH-responsive systems demonstrate incomplete drug release under physiological intracellular GSH levels (110 mM), suggesting an overestimation of redox sensitivity in vitro

| Glutathione Side Effects

Those results demonstrate that regulation of central metabolism is responsible for the observed robustness of cytosolic NADP redox status, which is itself a prerequisite for the previously-described robustness of the glutathione redox status

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