Patients experiencing poor sleep or high stress may find tirzepatide less effective despite adequate dosing
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2 Propensity score matching likely isnt adequately accounting for difference in baseline diabetes severity, especially since the commentators point to a high degree of missing HbA1c values and not including other diabetes complications like nephropathy, neuropathy and peripheral vascular disease
45 Products that are a combination of a DPP-4 inhibitor and an SGLT2 inhibitor (sitagliptin/ertugliflozin, saxagliptin/dapagliflozin, and linagliptin/empagliflozin) may be used to further lower A1C and provide increased CV benefit in patients who are not meeting A1C goals on dual therapy
The inter-individual variability was larger in the urinary than the salivary cortisol levels, which could be due to metabolic differences between individuals since urinary cortisol is metabolized before excretion 1,4