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This gap reflects a combination of limited clinician familiarity with prescribing guidelines, concerns about medication safety, and barriers to insurance coverage

The primary endpoint, and, unless indicated otherwise, all continuous secondary endpoints were analyzed for a treatment effect (dulaglutide versus placebo) using linear mixed-effect models (LMMs)

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(4) Intracellular TAAR1 activation: Elevated cytoplasmic tyramine activates trace amine-associated receptor 1 (TAAR1), promoting signaling pathways that result in phosphorylation of the NET transporter, modify transporter function to cause it to switch to reverse transport mode (rNET)

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