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How do leptin, ghrelin, injury, stress, and under-fueling affect weight regulation

The basis was the findings that DSIP modulates endogenous opioid peptidergic systems and has a significant effect on circadian rhythms and cortisol levels

doi: 10.1038/s41586-023-06758-2 30

Evidence extrapolated from other tissue types

Exendin 939 targets the extracellular side of the TRPV1 channel but does not share the CAP binding site Next, we examined the molecular target of exendin 939 on the TRPV1 channel via a patchclamp competition assay in CHO K1 cells expressing human TRPV1

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