L-Carnitine to promote weight loss in adults: a systematic review and meta-analysis of randomized controlled trials Pooyandjoo M, Nouhi M, Shab-Bidar S, Djafarian K, Olyaeemanesh A (2016)
People taking semaglutide experience a 26% reduction in major cardiovascular events (heart attack, stroke, cardiovascular death) compared to placebo, according to the SUSTAIN-6 triala benefit that extends beyond weight loss alone

Owners commonly notice one or more of the following: Limping or lameness: favoring a limb, "toe-touching," or intermittent limping that comes and goes Stiffness after rest: difficulty rising after sleeping, or a slow, stiff first few minutes that loosens with movement Reluctance to jump, climb, or use stairs: hesitating at the car, couch, or staircase they used to handle easily Reduced activity or stamina: shorter walks, less play, or lagging behind on familiar routes Audible joint changes: clicking or popping from a joint, particularly the stifle (knee) Muscle loss: visible thinning of the muscle on one hind limb compared with the other, a sign of chronic underuse Behavioral changes: licking a joint, irritability when a limb is handled, or a drop in overall mood tied to discomfort A sudden non-weight-bearing lameness the dog will not put any weight on a leg warrants prompt veterinary attention rather than watchful waiting, as it can indicate an acute cruciate rupture or fracture

Your anaesthetic and diabetes teams will assess your specific circumstances and provide tailored guidance
In some guidelines, diosmin is also discussed as a supportive therapy for lipoedema, as it improves microcirculation and reduces capillary fragility (lipoedema patients tend to bruise)
Any formula that promises to amp up my metabolism makes me wary that my sleep will be disrupted even more