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Some studies estimate that absorption may be as low as 1.3% from a 1000mcg dose, which is why you are likely to see supplements offering high doses

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Although treatment lowered serum homocysteine levels compared with placebo, no effect was seen on the progression of cognitive decline in patients with mild to moderate Alzheimer disease 26 or in preserving cognitive function in healthy adults

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B12 is also crucial for neurotransmitter function, improving mood and mental focus