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Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors

To overcome this limitation, various modifications and delivery strategies to enhance the pharmacokinetic properties and therapeutic efficacy of GLP-1 analogs have been studied

Studies have focused on energy homeostasis, body composition and metabolic pathway modulation via simultaneous incretin and glucagon engagement

Figure 30: Photograph of Professor Sir Stephen Bloom, 2013, credit: Bloom

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