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doi:10.7326/0003-4819-156-10-201205150-00004
Studies have shown that adipose tissue plays an important role as a pro-inflammatory factor in the pathogenesis of PCOS, and the release of tumor necrosis factor alfa (TNF-) and interleukin-6 (IL-6) from macrophages is associated with the induction of insulin resistance (67)
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Vitamin B6 is required for the normal release and function of the feel good chemical messengers serotonin, dopamine, and GABA
Limitations include limited large-scale human clinical evidence, challenges in extrapolating in-vitro concentrations to in-vivo contexts, stability sensitivities (light, heat, alkaline pH), and variability in supplier purity