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The available studies differ in drug type, dose, indication, timing of exposure, comparator structure, and baseline maternal metabolic risk, and the number of exposed pregnancies remains insufficient to exclude uncommon but clinically important harms (132, 133)

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Before injection, remove DUPIXENT from the refrigerator and allow DUPIXENT to reach room temperature (45 minutes for the 300 mg/2 mL pre-filled syringe or pre-filled pen, and 30 minutes for the 200 mg/1.14 mL pre-filled syringe or pre-filled pen) without removing the needle cap