Thats a wider pool of people than those who normally qualify for a GLP-1 prescription
If you experience serious side effects, stop taking the medication
Regulatory bodies approved GLP-1 receptor agonists for glycemic control include: Dulaglutide (subcutaneous-SC), exenatide injectable solution subcutaneous, exenatide injectable suspension SC, liraglutide SC, liraglutide/insulin degludec , lixisenatide/insulin glargine, semaglutide (oral, SC), tirzepatide (dual GIP/GLP-1 receptor agonist) and others
Natural GLP-1, GIP, and glucagon fire in short bursts and clear within minutes: GLP-1 and GIP after a meal, and glucagon during fasting or stress
The authors infer that small molecule GLP-1 receptor agonists are absorbed mainly from the small intestine, as their physicochemical characteristics contrast with oral semaglutide, of which the absorption site is the stomach
If the myostatin inhibitor pipeline delivers if apitegromab or a successor can preserve not just lean mass but functional strength the combination of a GLP-1 drug (for systemic metabolic and anti-inflammatory effects) with a myostatin inhibitor (for muscle preservation) could become the first pharmacological intervention that addresses both the fat-accumulation and muscle-decline axes of aging simultaneously
