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Study authors are generally careful to frame these effects as most pronounced within controlled research protocols that include structured training and caloric variables the literature does not describe IGF-1 LR3 as a standalone driver of fat loss independent of those conditions

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These findings should be viewed as hypothesis-generating , providing a systems-level context for the observed metabolite changes rather than evidence of causal normalization

Interestingly, PYY 136 binds to Y1R, Y2R, and Y5R, whereas PYY 336 has a high affinity for Y2R [80]

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