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This sequence composition appears optimized for survival in variable gastrointestinal pH environments ranging from gastric acid (pH 1.5-3.0) through intestinal alkaline conditions (pH 6.0-8.0)

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Martino MM, Tortelli F, Mochizuki M, Traub S, Ben-David D, Kuhn GA, et al

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Levels of NADP + /NADPH, crucial for mitochondrial antioxidant enzyme recycling, were not altered (Fig