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This translates to approximately 1.6 to 4 mcg per kilogram of body weight, extrapolated from effective rat doses using standard interspecies scaling factors

doi: 10.23736/S0392-0488.19.06458-7 2

The safety has not been well studied

Certain medications may require closer monitoring when taken with semaglutide, especially those that affect blood sugar, digestion, or appetite

When mitochondrial energy falls and reactive oxygen species rise, the effects may include cognitive slowing, poor stress tolerance, sensory overload, sleep disturbance, irritability, impaired impulse control, psychosis vulnerability, fatigue and reduced rehabilitation capacity