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Ambrosi N, Arrosagaray V, Guerrieri D, Uva PD, Petroni J, Herrera MB, Iovanna JL, Len L, Incardona C, Chuluyan HE, Casadei DH (2016) -Lipoic acid protects against ischemia-reperfusion injury in simultaneous kidney-pancreas transplantation

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In addition to the consensus on the prominent role of cystine starvation in blocking GSH synthesis, the present two studies demonstrated two previously under-appreciated metabolic effects that contribute to the ferroptosis-susceptible state in cancer cells under cystine deprivation conditions: loss of GPX4 protein translation and accumulation of oxidative stress-inducing intracellular glutamate (Fig