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These genes usually participate in intestinal immunity, the nuclear factor B (NF-B) signaling pathway, cytochrome P450 metabolism and melanoma formation.34 It has been confirmed that aloe leaves can inhibit CYP3A and CYP2D6 expression in vivo and that rhubarb can inhibit the P450 family through antimutation actions.35 DNA microarray analysis indicated that in tissues with MC, CYP3A4 expression was significantly decreased compared with that in normal tissue

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doi: 10.1016/j.clim.2013.04.006 104 PozzilliPLeslieRDPetersALBuzzettiRShankarSSMilicevicZet al