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Considering the above and given that hepatic fibrosis is the main histological prognostic factor for advanced NAFLD and a target that is difficult to reverse [51], it may be speculated that GLP-1RAs could possibly be provided in earlier stages of the disease before the occurrence of hepatic fibrosis

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Some patients carry variants associated with heightened sympathetic response, while others show blunted receptor sensitivity

Follow-up screening during the first year helps us detect changes when they are earliest and most responsive to treatment