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It is important to remember that human clinical research remains limited

Appendix 1 describes the literature search strategy

96 Safety B12 is considered safe even at high doses, and no adverse effects have been associated with excess B12 in healthy individuals

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This led to visible segregation between the different zones of the meniscus, with the peripheral vascularized zones being the red-red, the inner avascular region as the white-white zone, and the area in between as the red-white zone