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NNT activity contributes to 45% of the total NADPH in mitochondrial pool, indicating a significant role of NNT for NADPH pool maintenance, 111 and NADPH obtained by NNT is also used for the reductive carboxylation of -KG to isocitrate mediated by IDH2
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Recent data have shown a correlation between prooxidative processes and pain sensitization in FM subjects
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