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Based on these researches, clinical trials targeting HO-1 should be carried out to evaluate its application in the treatment of DN, so as to provide evidence for clinical application

These findings suggest oral administration can be effective, at least in rodent models

Finally, the Cas9 protein of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 system has been implicated in meningococcal ability to adhere to and invade the host cell, and especially to survive in the intracellular environment (Sampson et al., 2013)

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A proper gut microbiome is a prerequisite for UA production

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