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This study shows the beneficial therapeutic effect of pharmacological HIF2 inhibitor belzutifan in a murine model of polycythaemia, pulmonary hypertension, pulmonary fibrosis and complications due to gain-of-function mutation of HIF2A

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Long-Term Data: While short-to-medium term studies (up to several months) indicate safety, long-term safety data (over multiple years) in broad populations is still being gathered

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However, the distinction between opioids and opiates is becoming less relevant as synthetic opioids become more common and natural opiates are synthesized into semi-synthetic opioids